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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Arginine-linked HPV-associated E7 displaying bacteria-derived outer membrane vesicles as a potent antigen-specific cancer vaccine

Fig. 4

Characterization of splenocyte populations in SOMV-9RE7 vaccinated TC-1 tumor model. A Flow cytometry analysis of splenic lymphocyte population from previously described treatments by staining with APC-A700-conjugated anti-mouse CD45 and BV421-conjugated anti-mouse CD3 antibodies. B Percentage of CD45+ and CD3+ splenocyte population in each treatment group. C Cytotoxic lymphocyte population within splenic lymphocytes is identified by staining with PE-Cy5-conjugated anti-mouse CD8 antibody and D bar graph shows CD8+ T cells from each group. E Within CD8+ T cells, E7 antigen-specific T cells are gated with PE-conjugated HPV16 E7 tetramer and F E7+ populations are analyzed from each group. (G) E7-specific CTL effector function is presented by intracellular staining with BV650-conjugated IFNγ antibody and H percentage of IFNγ expression with bar graph

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Journal of Translational Medicine

ISSN: 1479-5876

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