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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Single-cell transcriptomics dissects the transcriptome alterations of hematopoietic stem cells in myelodysplastic neoplasms

Fig. 6

PLCB1 inhibitor U73122 affects cell cycle-related signaling pathways. (A) Volcano plots showing 1646 genes with the most statistically significant differences between U73122 (5µM) treated and untreated THP-1 cells.|LogFC|≥1 and p value < 0.05 were used to define DEGs. (B) Functional enrichment bar chart (KEGG terms) of DEGs in U73122 (5µM) treated THP-1 cells compared to untreated cells. P value < 0.05 was considered statistically significant for KEGG enrichment analysis. (C) Functional enrichment bar chart (GO terms) of DEGs in U73122 (5µM) treated THP-1 cell compared to untreated cells. P value < 0.05 was considered statistically significant for GO enrichment analysis. (D) GSEA revealing significantly enriched cell cycle-related signaling pathways (NES > 1, adjusted p value < 0.05). (E) Heatmap showing the expression of representative cyclins

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Journal of Translational Medicine

ISSN: 1479-5876

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