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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Single-cell transcriptomics dissects the transcriptome alterations of hematopoietic stem cells in myelodysplastic neoplasms

Fig. 4

Further investigation of MAML3 and PLCB1 in MDS. (A) Violin plots showing the expression of MAML3 in each cell cluster. (B, C) Identification of MAML3 as an upregulated gene in CD34 + HSPCs by integrating multiple Gene Expression Omnibus (GEO) datasets (GSE114922, and GSE111085). (D) RT-qPCR analyses of MAML3 mRNA in CD34 + HSPCs of MDS patients. (E) Violin plots showing the expression of PLCB1 in each cell cluster. (F, G) Identification of PLCB1 as an upregulated gene in CD34 + HSPCs by integrating GEO datasets (GSE114922 and GSE111085). (H) RT-qPCR analyses of PLCB1 mRNA in CD34 + HSPCs of MDS patients. (I) Left, representative images of immunohistochemical (IHC) staining of PLCB1 in BM biopsy specimens. Scale bar, 20 μm; Right, statistical analysis of PLCB1 immunohistochemistry score. (J) Kaplan–Meier survival analysis of overall survival (OS) in MDS patients. (K) OS of AML patients calculated by the online survival analysis tool “Kaplan-Meier Plotter” (KM plotter) database, including GSE1159, GSE12417, GSE37642, GSE6891 and GSE 8970 datasets

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Journal of Translational Medicine

ISSN: 1479-5876

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