Fig. 5
PrPC overexpression aggravates the development of mutant Apc driven CRC in mouse. A Relative quantification of lesion types according to genotype. B, C H&E staining sections from PRNP+/− mice, showing representative zones of high grade dysplasia (B, bottom panel) and low grade dysplasia (c, middle panel), as well as β-catenin staining (C, bottom panel). D, E H&E staining sections from PRNP+/+ mice, showing representative zones of infiltrating adenocarcinoma (D, bottom panels) and high grade dysplasia (E, middle panels), as well as β-catenin staining (E, bottom panels). Arrows indicate: a transition zone between normal cells and high grade dysplasia cells (B, bottom panel), mitoses (E, middle right panel), nuclear β-catenin (E, bottom right panel). Mice experiments were conducted as described in Additional file 1