Fig. 4

PrP^C sustains a vicious circle in an oncogenic Apc mouse model. A–F Boxplots showing the mRNA levels of human PRNP (A), and mouse App (B), Bace1 (C), Dkk3 (D), Pdgfc (E) and Tgfb1 (F) in normal or tumor tissue from VilCreER^T2Apc^fl/+-PRNP^+/− (PRNP_het) or VilCreER^T2Apc^fl/+-PRNP^+/+ (PRNP_hom) mice as measured through qRT-PCR. G-N Scatter plots showing the correlation between the mRNA levels of human PRNP and those of mouse App (G), Bace1 (H), Dkk3 (I), Pdgfc (J), Tgfb1 (K), Axin2 (L), Lgr5 (M) and Ccnd1 (N) in normal or tumor tissue from VilCreER^T2Apc^fl/+-PRNP^+/− or VilCreER^T2Apc^fl/+-PRNP^+/+ mice. O, P Boxplots showing the mRNA levels of mouse Axin2 (O) and Ccnd1 (P) in normal or tumor tissue from VilCreER^T2Apc^fl/+-PRNP^+/− (PRNP_het) or VilCreER^T2Apc^fl/+-PRNP^+/+ (PRNP_hom) mice as measured through qRT-PCR. Mice experiments were conducted as described in Additional file 1