Fig. 2

scRNA-seq analysis revealed the alteration of transcription programs in acinar cells. A UMAP plot of acinar derived from WT/CER samples (left) and subpopulations (right). B Scatter plot of DEGs (red points) in acinar cells showing the normalized expression level in CER (Y-axis) versus WT (X-axis) samples. The top 10 DEGs are highlighted by labels. C GO (left) and KEGG (right) enrichment analyses of DEGs in acinar cells based on GSEA. D UMAP plot visualizing the single-cell activity of specific pathways with GSVA scores. E Pseudotime trajectory of acinar cells in WT and CER samples. F Heatmap displaying the pseudotime changes of transcription factors (TFs) in acinar cells. G Binding motifs and expression regulatory network of the TFs in F