Fig. 1

Overview of single-cell transcriptional profiling of the pancreatic tissue. A UMAP plot of cells derived from WT/CER samples (left) and the 12 identified clusters (right). B Dotplot visualization of marker genes for each cluster. The size of the dots indicates the ratio of cells expressing this gene, and the shade of color represents the mean transcription levels in the corresponding clusters. C Relative proportion of each cell type in WT/CER samples. D GO (left) and KEGG (right) enrichment analyses of DEGs between the CER and WT samples based on GSEA