Table 2 Dark genes as components of edge biomarkers in LUAD and KIRC
From: Edge-based relative entropy as a sensitive indicator of critical transitions in biological systems
Gene | Associated edge biomarker | Type | Location | Family | Relation with tumors |
|---|---|---|---|---|---|
DKK1 | DKK1-FZD1 | Negative | Extracellular | Other | DKK1 guides epithelial-mesenchymal transition and promotes non–small cell lung cancer (NSCLC) invasion and metastasis [30] |
MYC | DKK1-MYC | Negative | Nucleus | Transcription factor | MYC functions as a metastasis promoter for NSCLC [31] |
WNT1 | DKK1-WNT1 | Negative | Plasma membrane | Other | WNT1 is closely related to tumor proliferation and angiogenesis in NSCLC [32] |
GAPDH | GAPDH-MYC | Negative | Cytosol | Enzyme | GAPDH is related to the proliferation and migration of lung cancer [33] |
GNG4 | GNB1-GNG4 | Negative | Plasma membrane | Other | GNG4 may promote the proliferation and metastasis of cancer cells by affecting their EMT progression [34] |
EGFR | EGFR-MYC | Negative | Endosome | Protein kinase | EGFR mutations usually result in tumor cellular proliferation in lung cancer [35] |
FOSL1 | FOSL1-MYC | Negative | Nucleus | Transcription factor | FOSL1 likely exerts essential functions in tumor growth and metastasis [36] |
NOG | BMP7-NOG | Negative | Extracellular | Other | NOG may inhibit tumor- suppressing properties of the BMPs and cause tumorigenesis [37] |