Fig. 4
From: Edge-based relative entropy as a sensitive indicator of critical transitions in biological systems
Dynamic evolution of networks consisting of ERE signaling edges in COAD, LUAD, THCA, and KIRC. A In COAD, the subnetwork composed of ERE signaling gene pairs evolved, with a clear distinction between stage IIB and other stages. B Similarly, there were clear changes in the subnetworks at stage IIIB for LUAD. C The subnetwork in THCA showed abrupt changes at stage II. D The subnetwork in KIRC also showed dramatic changes at stage II. The networks represent the aggregation of ERE values from all the samples within each time point