Fig. 3

CD137⁺ T cell subsets and sLAG3, were associated with response to ICIs in 55 NSCLC patients treated with immunotherapy as upfront treatment. A The scattered dot plots display the values of CD137⁺ (total, CD8⁺, and CD4⁺) and CD137⁺ PD1⁺ T cells in responder (R) and non-responder (NR) patients. B The histograms represent the median values of CD137⁺ and CD137⁺ PD1⁺ in patients with partial response (PR, in black), stable disease (SD, in dark grey), and progression (PD, in light grey) ± standard error of the mean (SEM). C The histograms showed the median values expressed in pg/mL of soluble LAG3 in R (black histograms) and NR (gray histograms) patients ± SEM. p values < 0.05 were considered significant