Table 1 PK parameters of DB-1310 (5Â mg/kg, i.v.) in the NCI-H441 model
Tissue | Analyte | Tmax | t1/2 | Cmax | AUC0 − t |
|---|---|---|---|---|---|
h | h | ng/mL | ng.h/mL | ||
Serum | ADC | 0.0830 | 119 | 90,996 | 4,355,036 |
Total antibody | 0.0830 | 118 | 79,688 | 3,766,065 | |
P1021 | 4.00 | 144 | 0.318 | 29.8 | |
Tumor | ADC | 48.0 | 88.4 | 5021 | 558,242 |
Total antibody | 48.0 | 87.8 | 4544 | 500,316 | |
P1021 | 24.0 | 59.9 | 6.27 | 424 |