Fig. 3

DB-1310 inhibits tumor growth in vivo. Immunodeficient mice were inoculated with NCI-H441 NSCLC cells (a), LU1542 NSCLC patient-derived tumor xenografts (b), HCC1569 breast cancer cells (c), Colo25 colon cancer cells (d), PR9586 prostate cancer patient-derived tumor xenografts (e) or PR9587 prostate cancer patient-derived tumor xenografts (f) and were then treated with DB-1310 or HER3-DXd. The tumor volume in each animal was measured twice a week