Table 2 List of genes and proteins that were consistently downregulated
Key target genes/proteins | CRISPR group | Mutation group | Difference comparison | |||
|---|---|---|---|---|---|---|
Gene expression | Protein expression | Gene expression | Protein expression | Genetic differences | Protein differences | |
Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | t-test | t-test | |
CTTN | 4436.2 ± 70.0 | 3469.0 ± 158.3 | 3739.5 ± 150.5 | 2907.3 ± 20.7 | 6.6E−03 | 2.4E−02 |
KCNJ2 | 266.0 ± 29.5 | 470.3 ± 33.0 | 22.2 ± 2.0 | 32.0 ± 3.9 | 4.7E−03 | 1.7E−03 |
ATP1B1 | 3683.1 ± 80.8 | 3517.6 ± 202.0 | 1727.6 ± 37.2 | 2851.8 ± 115.4 | 6.7E−05 | 1.4E−02 |