Fig. 6

Dynamics of chromatin accessibility during cardiomyocyte differentiation in the mutation and CRISPR groups. A, B Correlation analysis of the RNA-seq data and ATAC-seq data at different stages. The colors represent the Kendall correlation coefficients between samples, which were calculated using FPKM values for gene expression (for RNA-seq) and genome-wide chromatin accessibility (for ATAC-seq). The darker the color is, the higher the correlation. C Changes in overlapping open chromatin regions between different groups of cells and cell lines at different stages. D Motif analysis: matched motifs from the differential peaks in the ATAC-seq data from the mutation and CRISPR groups are shown. E Verification to determine whether the gene expression of the corresponding transcription factor in a specific time period correlates with an open chromatin state. The E-value is the enrichment p-value times the number of candidate motifs tested