Fig. 9

Chord diagram of associations between seven clinical symptoms and 13 DEG expression levels for all samples. Clinical symptoms are represented on the top part of the circle, while DEGs are represented on the bottom part of the circle. The arcs are colour-coded with red for positive effect and blue for negative effect. The width of the arc represents the gene effect on its corresponding clinical symptom. Fatigue score, from the Chalder Fatigue Questionnaire; Post-exertional malaise, from the DePaul Symptom Questionnaire; cognitive symptoms, the sum score across the 3 items memory problems, concentration problems, and decision-making problems; respiratory symptoms, the sum of scores across dyspnea and coughing; symptoms of anxiety, from the Hospital Anxiety and Depression Scale anxiety subscale; symptoms of depression, from the Hospital Anxiety and Depression Scale depression subscale; quality of life, from the Pediatric Quality of Life Inventory