Fig. 4

Differential gene expression analysis for participants divided into four experimental groups depending on prior SARS-CoV-2 infection and fatigue symptoms. A Volcano plot of differentially expressed genes for participants with prior SARS-CoV-2 infection and fatigue symptoms (SARS + /F +) relatively to fully recovered participants with SARS-CoV-2 infection (SARS + /F-). Genes with significantly increased expression are represented with red dots. The threshold for the adjusted p-value was set to 0.05. The grey dots indicate absolute value of log2 (fold-change) smaller than 0.50. FC, fold change; NS, non-significant. B Heat map of differentially expressed genes in participants with prior SARS-CoV-2 infection and fatigue symptoms (SARS + /F +) relative to participants in the other three groups, with raw expression values being scaled