Table 5 GO enrichment analysis of cellular component, biological process and molecular function categories of hub genes

1

RNA Polymerase III Complex (GO:0005666)

0.00003048

0.001006

332.92

3461.84

2

TORC2 Complex (GO:0031932)

0.003495

0.01648

370.07

2093.27

3

Cytosolic Small Ribosomal Subunit (GO:0022627)

0.0001826

0.001943

127.89

1100.92

4

Small Ribosomal Subunit (GO:0015935)

0.0001917

0.001943

124.69

1067.29

5

RNA Polymerase I Complex (GO:0005736)

0.005985

0.02195

201.81

1032.95

6

RNA Polymerase II, Core Complex (GO:0005665)

0.006979

0.02243

170.74

847.70

7

Cytosolic Large Ribosomal Subunit (GO:0022625)

0.0002944

0.001943

99.70

810.62

8

Large Ribosomal Subunit (GO:0015934)

0.0002944

0.001943

99.70

810.62

9

COPII Vesicle Coat (GO:0030127)

0.007476

0.02243

158.54

776.21

10

Ribosome (GO:0005840)

0.0004053

0.002229

84.45

659.65

Biological Process

Description

P-value

Adjusted p-value

Odds Ratio

Combined Score

1

Regulation of Pentose-Phosphate Shunt (GO:0043456)

0.002498

0.03953

555.17

3326.77

2

Positive Regulation of ER-associated Ubiquitin-Dependent Protein Catabolic Process (GO:1,903,071)

0.002997

0.03953

444.11

2580.41

3

Aggrephagy (GO:0035973)

0.002997

0.03953

444.11

2580.41

4

Cytoplasmic Translation (GO:0002181)

9.004e-8

0.00001855

149.07

2418.38

5

tRNA Transcription by RNA Polymerase III (GO:0042797)

0.003495

0.03953

370.07

2093.27

6

Regulation of Wound Healing, Spreading of Epidermal Cells (GO:1,903,689)

0.003495

0.03953

370.07

2093.27

7

Regulation of Myeloid Leukocyte Differentiation (GO:0002761)

0.003495

0.03953

370.07

2093.27

8

Regulation of Oxidative Stress-Induced Cell Death (GO:1,903,201)

0.003495

0.03953

370.07

2093.27

9

tRNA Transcription (GO:0009304)

0.003994

0.03953

317.19

1751.86

10

Modification-Dependent Macromolecule Catabolic Process (GO:0043632)

0.003994

0.03953

317.19

1751.86

Molecular Function

Description

P-value

Adjusted p-value

Odds Ratio

Combined Score

1

RNA Polymerase III Activity (GO:0001056)

0.00002354

0.0003531

384.17

4094.01

2

RNA Polymerase III Type 3 Promoter Sequence-Specific DNA Binding (GO:0001006)

0.002997

0.01101

444.11

2580.41

3

RNA Polymerase III Cis-Regulatory Region Sequence-Specific DNA Binding (GO:0000992)

0.003495

0.01101

370.07

2093.27

4

DNA-directed 5’-3’ RNA Polymerase Activity (GO:0003899)

0.0001252

0.0009387

155.92

1401.11

5

RNA Polymerase II Activity (GO:0001055)

0.004990

0.01176

246.68

1307.49

6

RNA Polymerase I Activity (GO:0001054)

0.005488

0.01176

222.00

1155.57

7

Polyubiquitin Modification-Dependent Protein Binding (GO:0031593)

0.02619

0.04911

42.60

155.17

8

Ribosome Binding (GO:0043022)

0.04171

0.06951

26.33

83.66

9

Kinase Activity (GO:0016301)

0.05176

0.07765

21.04

62.31

10

RNA Binding (GO:0003723)

0.003668

0.01101

8.81

49.38