Table 3 GO enrichment analysis of Cellular Component, Biological Process and Molecular Function categories of MCODE genes

1

Respiratory Chain Complex I (GO:0045271)

7.030e-12

4.921e-11

554.28

14234.30

2

Mitochondrial Respiratory Chain Complex I (GO:0005747)

7.030e-12

4.921e-11

554.28

14234.30

3

Respiratory Chain Complex III (GO:0045275)

0.00001235

0.00002469

555.03

6273.06

4

Mitochondrial Respiratory Chain Complex III (GO:0005750)

0.00001235

0.00002469

555.03

6273.06

5

Mitochondrial Respiratory Chain Complex IV (GO:0005751)

0.00003048

0.00005334

332.92

3461.84

6

Respiratory Chain Complex IV (GO:0045277)

0.00003830

0.00005958

293.72

2987.15

7

Mitochondrial Inner Membrane (GO:0005743)

8.018e-11

3.742e-10

126.16

2932.82

8

Organelle Inner Membrane (GO:0019866)

1.337e-10

4.678e-10

116.96

2659.16

9

Mitochondrial Membrane (GO:0031966)

1.126e-9

3.152e-9

85.18

1755.08

10

Mitochondrial Intermembrane Space (GO:0005758)

0.0004187

0.0005329

83.04

645.92

11

Mitochondrial Envelope (GO:0005740)

0.00004404

0.00006166

59.48

596.62

12

Organelle Envelope Lumen (GO:0031970)

0.0005036

0.0005876

75.47

573.09

13

Mitochondrial Matrix (GO:0005759)

0.1640

0.1766

6.16

11.14

14

Intracellular Organelle Lumen (GO:0070013)

0.3544

0.3544

2.49

2.58

Biological Process

Description

P-value

Adjusted p-value

Odds Ratio

Combined Score

1

Aerobic Electron Transport Chain (GO:0019646)

5.214e-19

7.324e-18

1328.67

55933.89

2

Mitochondrial ATP Synthesis Coupled Electron Transport (GO:0042775)

6.658e-19

7.324e-18

1285.68

53809.88

3

Cellular Respiration (GO:0045333)

3.390e-18

2.486e-17

1034.44

41611.25

4

Mitochondrial Electron Transport, NADH to Ubiquinone (GO:0006120)

2.614e-12

9.585e-12

688.31

18357.31

5

Aerobic Respiration (GO:0009060)

1.055e-13

5.804e-13

564.25

16859.87

6

Oxidative Phosphorylation (GO:0006119)

1.590e-13

6.997e-13

524.55

15458.46

7

NADH Dehydrogenase Complex Assembly (GO:0010257)

2.685e-11

6.564e-11

415.46

10112.50

8

Proton Motive Force-Driven Mitochondrial ATP Synthesis (GO:0042776)

2.685e-11

6.564e-11

415.46

10112.50

9

Mitochondrial Respiratory Chain Complex I Assembly (GO:0032981)

2.685e-11

6.564e-11

415.46

10112.50

10

Proton Motive Force-Driven ATP Synthesis (GO:0015986)

5.103e-11

1.123e-10

362.45

8589.64

11

Energy Derivation by Oxidation of Organic Compounds (GO:0015980)

3.852e-9

7.061e-9

341.04

6607.62

12

Mitochondrial Electron Transport, Ubiquinol to Cytochrome C (GO:0006122)

0.00001481

0.00002506

499.50

5554.53

13

Mitochondrial Respiratory Chain Complex Assembly (GO:0033108)

4.081e-10

8.163e-10

234.18

5062.76

14

ATP Synthesis Coupled Electron Transport (GO:0042773)

0.003495

0.005492

370.07

2093.27

15

Mitochondrial Electron Transport, Cytochrome C to Oxygen (GO:0006123)

0.007973

0.01169

147.96

714.91

16

Purine Ribonucleoside Triphosphate Metabolic Process (GO:0009205)

0.01589

0.02062

71.54

296.32

17

Apoptotic Mitochondrial Changes (GO:0008637)

0.01687

0.02062

67.20

274.29

18

ATP Metabolic Process (GO:0046034)

0.01687

0.02062

67.20

274.29

19

Regulation of Mitochondrial Membrane Potential (GO:0051881)

0.01933

0.02239

58.34

230.20

20

Purine Ribonucleotide Metabolic Process (GO:0009150)

0.04122

0.04535

26.65

84.98

21

Mitochondrion Organization (GO:0007005)

0.07813

0.08185

13.68

34.89

22

Apoptotic Process (GO:0006915)

0.1083

0.1083

9.67

21.50

Molecular Function

Description

P-value

Adjusted p-value

Odds Ratio

Combined Score

1

NADH Dehydrogenase (Ubiquinone) Activity (GO:0008137)

2.230e-12

5.228e-12

712.93

19127.14

2

Oxidoreduction-Driven Active Transmembrane Transporter Activity (GO:0015453)

6.053e-14

3.632e-13

623.19

18967.06

3

NADH Dehydrogenase (Quinone) Activity (GO:0050136)

2.614e-12

5.228e-12

688.31

18357.31

4

Cytochrome-C Oxidase Activity (GO:0004129)

0.005985

0.008978

201.81

1032.95

5

Active Monoatomic Ion Transmembrane Transporter Activity (GO:0022853)

0.01194

0.01433

96.46

427.12

6

Proton Transmembrane Transporter Activity (GO:0015078)

0.02228

0.02228

50.37

191.61