Fig. 10

Schematic diagram to show the relationship between TNFSF11 and ferroptosis. TNFSF11 overexpression leads to reduced GPX4 expression, thereby increasing cellular susceptibility to ferroptosis inducers such as ferrostatin-1 and erastin. In contrast, cells exhibiting low TNFSF11 expression coupled with high GPX4 levels demonstrate enhanced resistance to these inducers of ferroptosis