Lack of shared neoantigens in prevalent mutations in cancer

Table 3 Predicted neo-epitopes with an affinity value to the HLA alleles < 100 nM, derived from missense mutations, are listed with selected information

MISSENSE			TOT FREQ	TOP FREQ	TUMOR
PROTEIN	PEPTIDE	A*02:01
PIK3CA_H1047L	FMKQMNDAL	89.17	0.31%	N/A	N/A
PROTEIN	PEPTIDE	*A03:01**
PIK3CA_N345K	KILCATYVK	39.61	0.29%	N/A	N/A
PIK3CA_H1047L	ALHGGWTTK	35.26	0.31%	N/A	N/A
PROTEIN	PEPTIDE	*A24:02**
CTNNB1_S37F	SYLDSGIHF	44.06	0.27%	N/A	N/A
PROTEIN	PEPTIDE	*B08:02**
PIK3CA_H1047L	FMKQMNDAL	40.19	0.31%	N/A	N/A
PROTEIN	PEPTIDE	*B27:05**
GNA11_Q209L	FRMVDVGGL	99.13	0.42%	42.50%	Eye & adnexa
PROTEIN	PEPTIDE	*B39:01**
GNA11_Q209L	FRMVDVGGL	92.24	0.42%	42.50%	Eye & adnexa
PROTEIN	PEPTIDE	*B58:01**
PIK3CA_E726K	KTQKVQMKF	15.89	0.21%	N/A	N/A
TP53_R248W	SSCMGGMNW	14.01	1.05%	N/A	N/A
PROTEIN	PEPTIDE	*B15:01**
PIK3CA_R88Q	RQLCDLRLF	47.05	0.57%	N/A	N/A

The peptide sequences include the mutated aminoacid residue (bold & underlined). Values in the column of the haplotypes indicate the predicted affinity (nM). TOT FREQ: frequency in the TCGA database; TOP FREQ: top frequency in specific tumor; TUMOR: tumor type in which the top frequency is reported

ISSN: 1479-5876