Fig. 11From: Lack of shared neoantigens in prevalent mutations in cancerProspected evolution of tumor lesions. Cells with mutations presenting shared neoantigens are eliminated in the very early stages of tumor lesions, when a full TME is not present. Cells not expressing shared neoantigens can outgrow without immunological control to form a tumor lesion embedded in the TME, difficult to be attacked by T cellsBack to article page