Fig. 3

ECP treatment modulates the polarization between Tregs and Th17 cells in CIA mice. a The flow cytometry dot plots depict Tregs in No-CIA, PBS, MTX, ECP-MD and ECP-treated mice. b The flow cytometry dot plots depict Th17 cells across the same groups. c–e The splenic proportions of Tregs and Th17 cells were determined and are represented as individual data points. f Serum concentrations of cytokines IL-6, IL-17A, tumor necrosis factor and interferon-γ were measured for all groups. Data are shown as mean ± SEM. n = 5–6 for each group. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001