Fig. 6

AURKB promotes BC growth and downregulats p53 DDR pahway by regulating MAD2L2 expression in vivo. A Images of dissected T24 xenograft tumors. B, C Tumor volume and weight in each group.D Representative images of IHC staining for MAD2L2, KI67, CyclinD1 and p53 in each group. E Western blot analysis of AURKB, MAD2L2, CyclinD1, p53, p21 and γH2A.X expression in each group (The magnification under the microscope is shown as marked in the figure. *p < 0.05, **p < 0.01)