Fig. 1

RNA sequencing analysis revealed the positive correlation between HTRA1 and myocardial fibrosis in DCM. A Differential analysis of HTRA1 expression between DCM and NF patients based on six different datasets (n: GSE116250: DCM:NF = 37:14; GSE57388: DCM:NF = 82:136; GSE79962: DCM:NF = 9:11; GSE99321: DCM:NF = 7:7; GSE120895: DCM:NF = 47:8; GSE3585: DCM:NF = 7:5). B The correlation analysis between HTRA1 and fibrogenic genes such as α-SMA, Col1, Fib and CTGF (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). C Scatter plots showing the correlation between HTRA1 mRNA expression and tissue stromascores and fibroblasts abundance (Pearson’s chi-squared test was performed) D Hallmark and KEGG pathway enrichment analysis for HTRA1 using GSEA