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Table 2 Baseline characteristics of enrolled DR and non-DR participants

From: Statins as a risk factor for diabetic retinopathy: a Mendelian randomization and cross-sectional observational study

 

Total (N = 7569)

non-DR (N = 5949)

DR (N = 1620)

P val

Age (years)

63 (54,72)

63 (53,72)

64 (55,73)

0.055

Gender

   

0.776

 Female

 

2888 (48.55%)

780 (48.15%)

 

 Male

 

3061 (51.45%)

840 (51.85%)

 

Race

   

0.058

 Mexican American

1361 (17.98%)

1069 (17.97%)

292 (18.02%)

 

 Non-Hispanic Black

2063 (27.26%)

1611 (27.08%)

452 (27.90%)

 

 Non-Hispanic White

2663 (35.18%)

2137 (35.92%)

526 (32.47%)

 

 Other Hispanic

685 (9.05%)

520 (8.74%)

165 (10.19%)

 

 Other race—including multi-racial

797 (10.53%)

612 (10.29%)

185 (11.42%)

 

BMI(kg/m2)

   

0.128

 Low weight

30 (0.4%)

25 (0.5%)

5 (0.3%)

 

 Normal weight

974 (14.0%)

747 (13.6%)

227 (15.5%)

 

 Overweight

2091 (30.0%)

1679 (30.5%)

412 (28.1%)

 

 Obese

3877 (55.6%)

3054 (55.5%)

823 (56.1%)

 

HbA1c (%)

   

 < 0.001

 < 7.0

3629 (52.8%)

3001 (55.5%)

628 (43.1%)

 

  ≥ 7.0

3238 (47.2%)

2410 (44.5%)

828 (56.9%)

 

Triglyceride (mg/dl)

148 (101,220)

148 (101,220)

148 (99,221)

0.966

cholesterol (mg/dl)

176 (149,208)

176 (150,208)

174 (147,209)

0.615

Hypertension

   

 < 0.001

 No

2028 (26.9%)

1661 (28.0%)

367 (22.7%)

 

 Yes

5525 (73.1%)

4275 (72.0%)

1250 (77.3%)

 

Smoke

   

0.165

 Never

3766 (50.2%)

2938 (49.9%)

828 (51.2%)

 

 Former

2555 (34.1%)

1997 (33.9%)

558 (34.5%)

 

 Now

1182 (15.8%)

952 (16.2%)

230 (14.2%)

 

Alcohol consumption

   

 < 0.001

 Never

1132 (19.0%)

868 (18.5%)

264 (21.2%)

 

 Former

1524 (25.6%)

1157 (24.6%)

367 (29.5%)

 

 Mild

1975 (33.2%)

1600 (34.0%)

375 (30.1%)

 

 Moderate

597 (10.0%)

500 (10.6%)

97 (7.8%)

 

 Heavy

719 (12.1%)

577(12.3%)

142 (11.4%)

 

DM duration (years)

   

 < 0.001

 0–5

2484 (33.6%)

2168 (37.5%)

316 (19.7%)

 

 5–10

1593 (21.6%)

1310 (22.6%)

283 (17.7%)

 

 > 10

3312 (44.8%)

2309 (39.9%)

1003 (62.6%)

 

Statin use status

   

 < 0.001

 Not taking statins

414 (5.5%)

373(6.3%)

41 (2.5%)

 

 Taking other drugs

3278 (43.3%)

2604 (43.8%)

674 (41.6%)

 

 Taking statins

3877 (51.2%)

2972 (50.0%)

905 (55.9%)

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