Fig. 1

CAPE reduced mouse pathology and improved motor function after SCI. A HE staining images of the spinal cord centered around the injured core (3 mm) obtained at 28 dpi; Scale bar = 200, 100 μm. B Representative images of Nissl stained sections obtained from longitudinal sections centered at the injured core (3 mm) at 28 dpi. Scale bar = 200, 100 μm. C Representative images of LFB stained sections obtained from longitudinal sections centered around the injured core (3 mm) at 28 dpi; Scale bar = 200, 100 μm. D Quantitative analysis of the lesion area at 28 dpi; n = 6. E Quantitative analysis of survived neurons at 28 dpi; n = 6. F Quantitative analysis of the demyelinated area at 28 dpi; n = 6. G Footprint images of Sham, SCI, CAPE-treated and MP-treated SCI mice performed at 28 dpi. H BMS scores within 28 dpi in Sham, SCI, CAPE-treated and MP-treated SCI mice. Data are shown as means ± SEM. Statistical significance was determined with one-way ANOVA followed by Tukey’s post hoc test. ^#p < 0.05 vs. Sham group, *p < 0.05 vs. SCI group, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, n.s. = no significance