Fig. 5

Mice with Treg cell-specific PI16 ablation are protected from DSS-induced ulcerative colitis. A Diagram for the induction of DSS-induced colitis model; B the level of body weight in PI16^CKO and PI16^fl/fl mice during the colitis model process; C Clinical score of DSS-induced colitis in PI16^CKO and PI16^fl/fl mice. D The length of the distal colon of DSS-induced colitis in PI16^CKO and PI16^fl/fl mice. Graphs show the quantitation data derived from the left figure (n = 3, 63.33 ± 3.38 vs. 73.33 ± 1.86, p = 0.061); E HE staining of distal colon harvested on day 10 of DSS treatment (The magnification of first and third line is 40×; the magnification of second and fourth line is 100×) and Histology score (n = 5, 3.50 ± 0.16 vs. 2.10 ± 0.19, p = 0.0007) ns: p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001