Table 2 MR analysis to investigate potential causal relationships between risk proteins and other HLA-B27( +) diseases
Protein | Diseases | Diseases reference | Sample size | Method | Nsnp | OR (95% CI) | P(MR) | Steiger Test | P(ST) | Steiger Filtering | P(SF) |
|---|---|---|---|---|---|---|---|---|---|---|---|
AIF1 | Reactive arthropathies | FinnGen | 243,675 | Wald ratio | 1 | 0.64(0.53–0.78) | 5.21E−06 | Passed | 4.51E−95 | Passed | 2.64E−88 |
Psoriatic arthropathies | FinnGen | 244,048 | Wald ratio | 1 | 1.00(0.84–1.2) | 0.992226967 | Passed | 1.15E−103 | Passed | 1.37E−96 | |
Enteropathic arthropathies | FinnGen | 241,517 | Wald ratio | 1 | 0.68(0.46–1.01) | 0.056096383 | Passed | 5.70E−100 | Passed | 5.01E−93 | |
Inflammatory bowel disease | FinnGen | 377,277 | Wald ratio | 1 | 0.98(0.88–1.11) | 0.788875671 | Passed | 1.0759E−104 | Passed | 1.56355E−97 | |
VARS | Reactive arthropathies | FinnGen | 243,675 | Wald ratio | 1 | 0.36(0.21–0.63) | 0.000267246 | Passed | 2.14808E−18 | Passed | 1.38055E−17 |
Psoriatic arthropathies | FinnGen | 244,048 | Wald ratio | 1 | 0.57(0.35–0.92) | 0.022049658 | Passed | 1.74869E−19 | Passed | 1.19174E−18 | |
Enteropathic arthropathies | FinnGen | 241,517 | Wald ratio | 1 | 0.43(0.14–1.26) | 0.121746744 | Passed | 4.45692E−20 | Passed | 3.13235E−19 | |
Inflammatory bowel disease | FinnGen | 377,277 | Wald ratio | 1 | 1.47(1.07–2.02) | 0.018367358 | Passed | 4.9002E−20 | Passed | 3.48487E−19 |