Table 1 Steiger test and Steiger filtering estimates for the causal direction between plasma proteins to AS and iridocyclitis
Protein | Outcome name | outcome reference | Steiger test correct causal direction | Steiger test pval | SNP | Steiger filtering correct causal direction | Steiger_pval |
|---|---|---|---|---|---|---|---|
Plasma.AGER | Ankylosing spondylitis | FinnGen | TRUE | 1.0997E−94 | rs2070600 | TRUE | 1.3867E−90 |
Plasma.AIF1 | Ankylosing spondylitis | FinnGen | TRUE | 7.48619E−85 | rs2261033 | TRUE | 1.84802E−78 |
Plasma.CFB | Ankylosing spondylitis | FinnGen | TRUE | 1.8097E−183 | rs641153 | TRUE | 8.8334E−210 |
Plasma.COL11A2 | Ankylosing spondylitis | FinnGen | TRUE | 1.03009E−54 | rs3129205 | TRUE | 7.15834E−52 |
Plasma.TNXB | Ankylosing spondylitis | FinnGen | TRUE | 6.8159E−182 | rs45451301 | TRUE | 0 |
Plasma.VARS | Ankylosing spondylitis | FinnGen | TRUE | 1.51682E−15 | rs453821 | TRUE | 8.31624E−15 |
Plasma.AIF1 | Ankylosing spondylitis | UK Biobank | FALSE | 5.8074E−25 | rs2261033 | FALSE | 5.21377E−24 |
Plasma.APOM | Ankylosing spondylitis | UK Biobank | TRUE | 7.42183E−18 | rs2255741 | TRUE | 1.96695E−17 |
Plasma.BTN3A3 | Ankylosing spondylitis | UK Biobank | TRUE | 1.20084E−58 | rs9393711 | TRUE | 0 |
Plasma.C4A|C4B | Ankylosing spondylitis | UK Biobank | FALSE | 0.002663452 | rs3117580 | FALSE | 0.00444648 |
Plasma.CARD9 | Ankylosing spondylitis | UK Biobank | TRUE | 1.60674E−07 | rs4077515 | TRUE | 3.84782E−08 |
Plasma.ERAP1 | Ankylosing spondylitis | UK Biobank | TRUE | 1.8175E−115 | rs27895 | TRUE | 2.00675E−08 |
| Â | Â | Â | Â | Â | rs467735 | TRUE | 0 |
|  |  |  |  |  | rs62364719 | TRUE | 5.50478E−85 |
Plasma.FCGR2A | Ankylosing spondylitis | UK Biobank | TRUE | 3.41195E−66 | rs4657041 | TRUE | 0 |
Plasma.HP | Ankylosing spondylitis | UK Biobank | TRUE | 1.9314E−181 | rs77303550 | TRUE | 5.8206E−282 |
Plasma.ITLN1 | Ankylosing spondylitis | UK Biobank | TRUE | 3.6041E−07 | rs7532133 | TRUE | 1.03467E−06 |
Plasma.SFTPB | Ankylosing spondylitis | UK Biobank | TRUE | 2.16399E−07 | rs11126996 | TRUE | 7.75119E−07 |
Plasma.VARS | Ankylosing spondylitis | UK Biobank | FALSE | 0.000107735 | rs453821 | FALSE | 7.23814E−05 |
Plasma.AGER | Acute or subacute iridocyclitis | FinnGen | TRUE | 3.183E−101 | rs2070600 | TRUE | 5.84831E−97 |
Plasma.AIF1 | Acute or subacute iridocyclitis | FinnGen | TRUE | 1.95201E−92 | rs2261033 | TRUE | 1.01221E−85 |
Plasma.COL11A2 | Acute or subacute iridocyclitis | FinnGen | TRUE | 1.05049E−52 | rs3129205 | TRUE | 6.62665E−50 |
Plasma.VARS | Acute or subacute iridocyclitis | FinnGen | TRUE | 8.05775E−18 | rs453821 | TRUE | 5.08133E−17 |
Plasma.AIF1 | Chronic iridocyclitis | FinnGen | TRUE | 8.1108E−98 | rs2261033 | TRUE | 6.64628E−91 |