Fig. 2

Preliminary MR analysis and colocalization analysis of pCAM proteins with AS, iridocyclitis and its subtypes. A Manhattan plot for AS, iridocyclitis and its subtypes. B Study of causal relationships between circulating proteins and AS, iridocyclitis and their subtypes using MR analysis. C–F Volcano plots of MR results for plasma proteins on the risk of AS (C), iridocyclitis (D), acute and subacute iridocyclitis (E) and chronic iridocyclitis (F). The horizontal black dotted line corresponds to the Bonferroni-corrected P value. G Bayesian colocalization results support the results of MR analysis. OR, increased risk of disease was expressed as a percentage of the SD increase in plasma protein levels; p value, proportion of variance explained. PPs H1-H4, posterior probabilities supporting the colocalization hypothesis