Multi-omics analysis of the gut microbiome and metabolites associated with the psychoneurological symptom cluster in children with cancer receiving chemotherapy

Table 3 Eigenvector centrality of psychoneurological symptoms in the microbiome–metabolome networks and centrality differences between groups

Symptoms	Children with cancer		Healthy controls (n = 14)	T₁ vs. T₀	Healthy controls vs. T₀	Healthy controls vs. T₁
Symptoms	T₀ (n = 21)	T₁ (n = 12)	Healthy controls (n = 14)	T₁ vs. T₀	Healthy controls vs. T₀	Healthy controls vs. T₁
Pain	0.004	0	0	0.004	0.004	0
Fatigue	0.003	0	0.029	0.003	0.026	0.029
Anxiety	0.003	0	0.167	0.003	0.164	0.167
Depression	0.009	0	0.087	0.009	0.078	0.087
Cognition	0	0.586	0	0.586	0	0.586

T₀: pre-cycle two chemotherapy; T₁: post chemotherapy (completion of all chemotherapy)

ISSN: 1479-5876