Fig. 2
Integrative network analysis of gut microbiome, gut metabolome and psychoneurological symptoms. A Presents the network correlations for children pre-cycle two chemotherapy (T0), B for post-chemotherapy (T1), and C for healthy controls. The three-way multiomics analysis describes the network relationships among gut microbiome (rectangles), metabolites (circles), and PNS (triangles), including A 6 distinct communities (C1…C6) detected for the children with cancer group at T0, B 5 distinct communities (C1…C5) detected for the children with cancer group at T1, and C 6 distinct communities (C1…C6) detected for healthy controls. Within each panel A, B, or C, Table 2 presents the total number of microbes and metabolites linked with each cluster with specific symptom clusters. Table 4 and Fig. 4 further present these specific gut microbes and metabolites linked with specific clusters with PNS by the study groups