Lactate infusion elevates cardiac output through increased heart rate and decreased vascular resistance: a randomised, blinded, crossover trial in a healthy porcine model

Table 4 A-CS difference of metabolites across the heart

	Mean after 120 min		Linear mixed model
	Control	Lactate	Change compared with control	95% CI	P-value	P-value for interaction
Lactate (mmol/L)	0.17 ± 0.29	1.40 ± 0.82	1.20	0.56 to 1.90	0.002	0.4
Glucose (mmol/L)	-0.07 ± 0.44	-0.02 ± 0.48	0.08	-0.46 to 0.63	0.8	0.6
FFA (mmol/L)	0.04 ± 0.34	0.31 ± 0.33	0.42	0.03 to 0.80	0.054	0.7
Oxygen (ml/dL)	7.60 ± 2.20	6.50 ± 2.30	-1.80	-3.30 to -0.18	0.041	0.5

Mean values are expressed as mean ± standard deviation (SD). Mean values of the A-CS difference of metabolites and oxygen across the heart after 120 min of each infusion calculated as A-CS difference. Change compared with control is the development in A-CS difference during lactate infusion compared with control infusion. Bold value indicate p < 0.05
FFA free fatty acids

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