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Table 2 Haemodynamic parameters

From: Lactate infusion elevates cardiac output through increased heart rate and decreased vascular resistance: a randomised, blinded, crossover trial in a healthy porcine model

 

Mean after 120 min

Linear mixed model

Control

Lactate

Change compared with control

95% CI

P-value

P-value for interaction

Pulmonary artery measurements

CO (L/min)

4.3 ± 0.9

6.2 ± 0.9

2.0

1.2 to 2.7

 < 0.001

0.6

HR (bpm)

76 ± 27

88 ± 12

21

8 to 33

0.003

0.7

SV (mL)

61 ± 18

72 ± 12

2.4

 -13.0 to 18.0

0.8

0.5

SvO2 (%)

65 ± 8

73 ± 6

11

6 to 16

 < 0.001

0.051

P(v-a)CO2 (kPa)

1.60 ± 0.59

0.84 ± 0.53

 -0.73

 -1.10 to -0.35

 < 0.001

0.4

MAP (mmHg)

87 ± 12

85 ± 15

 -3

 -8 to 2

0.2

0.7

mPAP (mmHg)

16 ± 3.6

18 ± 3.1

2

 -2 to 7

0.4

0.6

RAP (mmHg)

5 ± 3

5 ± 2

 -2

 -4 to 1

0.2

0.2

PAWP (mmHg)

7 ± 3

8 ± 2

 -1

 -4 to 3

0.8

0.2

SVR (dynes/s/cm5)

1562 ± 335

1042 ± 208

 -548

 -835 to -261

 < 0.001

 > 0.9

PVR (dynes/s/cm5)

189 ± 114

150 ± 42

4

 -111 to 126

 > 0.9

0.2

Pressure–volume loop measurements

Ea (mmHg/mL)

3.0 ± 1.8

1.9 ± 0.85

 -1.0

 -2.0 to  -0.1

0.046

0.5

Ees (mmHg/mL)

0.82 ± 0.27

0.67 ± 0.18

 -0.01

 -0.31 to 0.29

 > 0.9

0.2

LVESV (mL)

150 ± 38

115 ± 27

 -51.0

 -94.0 to -6.9

0.032

0.7

LVEDV (mL)

195 ± 35

173 ± 26

 -31

 -74 to 12

0.2

0.7

LVESP (mmHg)

108.0 ± 15.0

103.0 ± 21.0

 -13.0

 -23.0 to -4.2

0.009

0.6

LVEDP (mmHg)

16.0 ± 5.6

15.0 ± 3.1

 -3.9

 -8.7 to 0.8

0.11

0.8

Pmax (mmHg)

111.0 ± 15.0

109.0 ± 18.0

 -9.7

-19.0 to  -0.4

0.050

0.7

LVEF (%)

25.0 ± 14.0

37.0 ± 13.0

16.0

1.1 to 32.0

0.056

 > 0.9

dP/dtmax (mmHg × s−1)

1315 ± 375

1741 ± 448

502

268 to 737

 < 0.001

0.2

Tau (ms)

36.0 ± 12.0

39.0 ± 11.0

5.0

 -3.7 to 14.0

0.3

0.6

LVEDPVR (mmHg × mL)

0.41 ± 1.10

0.03 ± 0.05

 -0.37

 -1.10 to 0.34

0.3

0.5

PVA (mmHg × mL)

9312 ± 6843

8589 ± 3997

 -2113

-7645 to 3418

0.5

0.3

Potential energy (mmHg × mL)

5464 ± 5087

4405 ± 2408

 -3174

 -7188 to 841

0.13

0.4

Cardiac efficiency (%)

46 ± 10

51 ± 16

19

6 to 31

0.008

0.7

Stroke work (mmHg × mL)

4634 ± 2827

6330 ± 3594

2730

 -48 to 5535

0.078

0.6

  1. Mean values are expressed as mean ± SD. Mean values of haemodynamic parameters measured using the PA catheter and the LV PV admittance catheter after 120 min of each infusion. Change compared with control is the development in each outcome during lactate infusion compared with control infusion. Bold values indicate p < 0.05
  2. CO cardiac output, HR heart rate, SV stroke volume, SvO2 mixed venous saturation, P(v-a)CO2 veno-arterial carbon dioxide difference, MAP mean arterial pressure, mPAP mean pulmonary artery pressure, RAP right atrium pressure, PAWP pulmonary artery wedge pressure, SVR systemic vascular resistance, PVR pulmonary vascular resistance, Ea arterial elastance, Ees end systolic elastance (the slope of the end systolic pressure–volume relationship [ESPVR]), ESV end systolic volume, EDV end diastolic volume, ESP end systolic pressure, EDP end diastolic pressure, Pmax maximum pressure, EF ejection fraction, dP/dtmax peak dP/dt, EDPVR end diastolic pressure–volume relationship, PVA pressure–volume area
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Journal of Translational Medicine

ISSN: 1479-5876

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