Fig. 7

ITGA6/PI3K/Akt pathway exerts promoting function in the radioresistance of NSCLC cells. A ITGA6 mRNA expression in H460 and H1229 cells treated with oe-ITGA6 or sh-ITGA6, respectively, measured by RT-qPCR. B Western blot of PI3K/Akt pathway-related proteins in H460 and H1229 cells treated with oe-ITGA6 or sh-ITGA6, respectively. C Viability of H460 and H1229 cells treated with oe-ITGA6 or sh-ITGA6, respectively, following exposure to different doses of X-ray radiation. D Proliferation of H460 and H1229 cells treated with oe-ITGA6 or sh-ITGA6, respectively, following exposure to 6 Gy X-ray radiation. E Invasion of H460 and H1229 cells treated with oe-ITGA6 or sh-ITGA6, respectively, following exposure to 6 Gy X-ray radiation. F γH2ax fluorescence in H460 and H1229 cells treated with oe-ITGA6 or sh-ITGA6, respectively, following exposure to 6 Gy X-ray radiation. G Apoptosis of H460 and H1229 cells treated with oe-ITGA6 or sh-ITGA6, respectively, following exposure to 6 Gy X-ray radiation determined by flow cytometry. H Cell cycle distribution of H460 and H1229 cells treated with oe-ITGA6 or sh-ITGA6, respectively, following exposure to 6 Gy X-ray radiation determined by flow cytometry. *p < 0.05 vs. oe-NC group. ^#p < 0.05 vs. sh-NC group. Cell experiments were repeated three times