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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Single-cell transcriptomic sequencing data reveal aberrant DNA methylation in SMAD3 promoter region in tumor-associated fibroblasts affecting molecular mechanism of radiosensitivity in non-small cell lung cancer

Fig. 3

Increased expression of SMAD3 in NSCLC is correlated with its promoter hypomethylation. A The DNA methylation level of the SMAD3 promoter region between normal tissues and LUAD tissues analyzed by the UALCAN database. B The DNA methylation level of the SMAD3 promoter region between normal tissues and LUSC tissues analyzed by the UALCAN database. C The DNA methylation level of the SMAD3 promoter region between normal tissues and LUAD tissues analyzed by the DNMIVD database. D The DNA methylation level of the SMAD3 promoter region between normal tissues and LUSC tissues analyzed by the DNMIVD database. E Correlation between SMAD3 expression and DNA methylation of the SMAD3 promoter region in TCGA-LUAD (n = 465). F Correlation between SMAD3 expression and DNA methylation of the SMAD3 promoter region in TCGA-LUSC (n = 370). G The DNA methylation level of the SMAD3 promoter region between the SMAD3 high (n = 233) and low expression groups (n = 232) in TCGA-LUAD. H The DNA methylation level of the SMAD3 promoter region between the SMAD3 high (n = 185) and low expression (n = 185) groups in TCGA-LUSC. I The DNA methylation level of the SMAD3 promoter region in promoter region in the tumor tissues of NSCLC patients detected by MSP-PCR (8 samples randomly selected from 120 samples)

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Journal of Translational Medicine

ISSN: 1479-5876

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