Fig. 5
From: MicroRNA-21a-5p inhibition alleviates systemic sclerosis by targeting STAT3 signaling
MiRNA-21a-5p inhibition decreases inflammatory cell infiltration into the lesional skin of bleomycin-induced SSc mice. On days 14, 21, and 28 from the start of bleomycin injection, plasmid containing of 100 μg scrambled anti-miR (n = 5) or anti-miRNA-21a-5p (n = 5) in 1 mL saline was hydrodynamically injected into the mice. The mice were sacrificed on day 33 from the start of bleomycin injection, and skin tissue sections were immunohistochemically stained for TNF-α, IL-β, IL-6, and IL-17. The graphs present the number of antibody-positive cells (mean ± SD, n = 5/group). Original magnification: 200 × . Scale bar: 100 µm