- Scoring based on technical assessment of the functional potential of an optimized product
- ? Conditional effect beyond direct scope of therapeutic determined by the induction of pro-inflammatory signals by dying cancer cells (Example is in Fig. 1 D); $ Depending upon quality of product before administration and favorable TME conditions
- mAbs/engagers include multi-specific mAbs including and CD3-based T cell engagers and similar. ADC = antibody drug conjugates
- Genetic payloads include methods for delivery of genetic material short of cellular product or molecularly engineered nanoparticles
- Basic CAR Cell (CAR-carrying cell products) with no enhancements based on modern synthetic biology approaches [47]
- Armored CAR-T (or other cell products) = next generation CAR-T cells or other cell products that may include conditional and reversible gene activation, logic gating for accurate tumor antigen recognition [47]
- Targeted delivery = nanoparticles molecularly engineered to deliver anti-tumoral payloads[48]
