Fig. 6

Scatter plot of representative biological processes enriched by URs modulated by DHA treatment. Starting from whole genome profiling data of untreated and DHA-treated GBM (#14), MM-BM (#12) and MM (#11) cell lines, comparative IPA analyses of biological processes enriched by URs was performed. Pink squares represent biological processes enriched by URs significantly activated (#1) or inhibited (#3) after guadecitabine treatment and shared by A GBM and MM-BM and/or by B GBM and MM cell lines. Light blue squares represent biological processes enriched by URs significantly activated (#2) or inhibited (#4) after guadecitabine treatment exclusively in A GBM compared to MM-BM or in B GBM compared to MM cell lines. The grey squares represent area of no-significance for Z-score and p-value. Gene Set Enrichment Analysis of genes belonging to each cluster was performed by EnrichR tool. Representative biological processes among the top 50 are listed in the scatter plot: X axis reports the Combined Score of significant enriched GO terms; size of the dot represents the significance of GO terms; colour of the dot represents the different cluster identified by the clustering technique