Development and validation of a model and nomogram for breast cancer diagnosis based on quantitative analysis of serum disease-specific haptoglobin N-glycosylation

Li, Linrong; Xu, Yali; Lai, Zhizhen; Li, Dan; Sun, Qiang; Li, Zhili; Zhou, Yidong

doi:10.1186/s12967-024-05039-4

Table 2 Baseline clinical characteristics of patients

From: Development and validation of a model and nomogram for breast cancer diagnosis based on quantitative analysis of serum disease-specific haptoglobin N-glycosylation

Characteristic	Unmatched			Propensity score matched
	Benign	Malignant	P-value	Benign	Malignant	P-value
	(N = 235)	(N = 262)	P-value	(n = 191)	(n = 191)	P-value
Age (years)
Mean (SD)	44.6 (11.1)	53.0 (11.8)	< 0.001	47.2 (10.4)	49.7 (11.3)	0.055
Median [Min, Max]	43.0 [26.0, 74.0]	52.5 [29.0, 75.0]		46.0 [26.0, 74.0]	48.0 [29.0, 75.0]
BMI (kg/m2)
< = 24	159 (67.7%)	157 (59.9%)	0.090	120 (62.8%)	123 (64.4%)	0.832
> 24	76 (32.3%)	105 (40.1%)		71 (37.2%)	68 (35.6%)
CEA (ng/mL)
Mean (SD)	1.4 (0.7)	2.3 (1.8)	< 0.001	1.5 (0.7)	2.1 (1.6)	< 0.001
Median [Min, Max]	1.3 [0, 3.9]	1.7 [0, 17.2]		1.3 [0.4, 3.9]	1.6 [0, 9.1.0]
CA125 (U/mL)
Mean (SD)	16.6 (13.1)	18.7 (49.3)	0.070	16.0 (13.4)	20.4 (55.8)	0.633
Median [Min, Max]	13.1 [4.7, 113.0]	11.7 [2.3, 762.0]		12.4 [4.7, 113.0]	12.2 [2.3, 762.0]
CA153 (U/mL)
Mean (SD)	9.4 (5.0)	13.3 (20.0)	< 0.001	9.4 (4.8)	13.6 (23.0)	< 0.001
Median [Min, Max]	7.8 [0, 30.4]	10.3 [3.1, 320.0]		7.8 [2.8, 30.4]	10.7 [3.10, 320.0]
ALT (U/L)
Mean (SD)	17.9 (16.1)	17.6 (14.8)	0.430	19.0 (17.2)	17.0 (14.8)	0.349
Median [Min, Max]	13.0 [0, 153.0]	14.0 [0, 131.0]		14.0 [6.0, 153.0]	13.0 [0, 131.0]
AST (U/L)
Mean (SD)	18.6 (7.6)	19.1 (9.0)	0.625	18.9 (7.9)	18.7 (8.1)	0.464
Median [Min, Max]	17.0 [9.0, 65.0]	17.0 [9.0, 93.0]		17.0 [9.0, 65.0]	17.0 [9.0, 73.0]
ChE (kU/L)
Mean (SD)	8.8 (1.6)	8.9 (1.6)	0.203	8.9 (1.5)	8.7 (1.5)	0.325
Median [Min, Max]	8.6 [4.8, 13.6]	8.9 [4.3, 13.1]		8.7 [5.8, 13.6]	8.6 [4.9, 13.1]
TC (mmol/L)
Mean (SD)	4.9 (0.8)	5.1 (1.0)	0.023	5.0 (0.8)	5.1 (1.0)	0.633
Median [Min, Max]	4.9 [1.7, 8.4]	5.0 [2.7, 8.8]		4.9 [1.7, 8.4]	5.0 [2.7, 8.8]
TG (mmol/L)
Mean (SD)	1.1 (0.8)	1.4 (1.0)	< 0.001	1.2 (0.8)	1.3 (0.9)	0.884
Median [Min, Max]	0.9 [0.3, 7.4]	1.1 [0.3, 7.4]		1.0 [0.3, 7.4]	1.0 [0.3, 6.0]
HDLC (mmol/L)
Mean (SD)	1.5 (0.3)	1.4 (0.3)	0.228	1.4 (0.3)	1.4 (0.3)	0.857
Median [Min, Max]	1.4 [0.5, 2.5]	1.4 [0.8, 2.3]		1.4 [0.5, 2.5]	1.4 [0.8, 2.2]
LDLC (mmol/L)
Mean (SD)	3.0 (0.7)	3.2 (0.9)	0.053	3.1 (0.7)	3.1 (0.9)	0.986
Median [Min, Max]	3.0 [0.7, 6.6]	3.1 [1.1, 6.9]		3.1 [0.7, 6.6]	3.0 [1.1, 6.9]
ApoA1 (g/L)
Mean (SD)	1.6 (0.3)	1.6 (0.2)	0.515	1.6 (0.3)	1.6 (0.2)	0.621
Median [Min, Max]	1.5 [0.8, 3.2]	1.5 [1.1, 2.5]		1.5 [0.8, 3.2]	1.5 [1.1, 2.5]
ApoB (g/L)
Mean (SD)	0.9 (0.2)	1.0 (0.2)	0.002	0.9 (0.2)	0.9 (0.3)	0.805
Median [Min, Max]	0.9 [0.4, 1.7]	0.9 [0.4, 2.6]		0.9 [0.4, 1.7]	0.9 [0.4, 2.6]
Lpa (mg/L)
Mean (SD)	138.0 (170.0)	163.0 (176.0)	0.004	143.0 (171.0)	146.0 (151.0)	0.281
Median [Min, Max]	74.0 [21.0, 890.0]	97.5 [19.0, 968.0]		82.0 [21.0, 890.0]	87.0 [19.0, 968.0]
FFA (μmol/L)
Mean (SD)	604.0 (230.0)	638.0 (252.0)	0.132	613.0 (225.0)	627.0 (246.0)	0.663
Median [Min, Max]	597.0 [103.0, 1370.0]	620.0 [103.0, 1490.0]		604.0 [103.0, 1290.0]	604.0 [103.0, 1310.0]
hsCRP (mg/L)
Mean (SD)	1.1 (1.5)	1.24 (1.63)	0.166	1.1 (1.6)	1.1 (1.4)	0.856
Median [Min, Max]	0.6 [0, 12.5]	0.7 [0, 13.8]		0.6 [0, 12.5]	0.6 [0, 8.4]
Glu (mmol/L)
Mean (SD)	5.3 (0.8)	5.5 (1.0)	0.006	5.4 (0.8)	5.5 (1.0)	0.344
Median [Min, Max]	5.2 [4.0, 9.5]	5.3 [4.0, 12.6]		5.2 [4.0, 9.5]	5.3 [4.0, 12.6]
WBC (10⁹/L)
Mean (SD)	5.8 (1.6)	5.7 (1.4)	0.971	5.8 (1.5)	5.6 (1.4)	0.197
Median [Min, Max]	5.5 [3.0, 11.5]	5.5 [2.7, 11.5]		5.6 [3.0, 11.1]	5.5 [2.7, 11.1]
LY (10⁹/L)
Mean (SD)	1.6 (0.4)	1.6 (0.5)	0.480	1.6 (0.5)	1.6 (0.5)	0.145
Median [Min, Max]	1.5 [0.6, 3.0]	1.5 [0.7, 4.9]		1.5 [0.6, 3.0]	1.5 [0.7, 4.9]
MONO (10⁹/L)
Mean (SD)	0.3 (0.1)	0.3 (0.1)	0.060	0.3 (0.1)	0.3 (0.1)	0.910
Median [Min, Max]	0.3 [0.1, 0.8]	0.3 [0.1, 1.0]		0.3 [0.1, 0.8]	0.3 [0.1, 1.0]
NEUT (10⁹/L)
Mean (SD)	3.8 (1.3)	3.7 (1.3)	0.896	3.8 (1.3)	3.7 (1.3)	0.220
Median [Min, Max]	3.6 [1.5, 9.2]	3.5 [1.2, 8.9]		3.6 [1.5, 8.9]	3.5 [1.2, 8.9]
PLT (10⁹/L)
Mean (SD)	253.0 (57.6)	242.0 (51.7)	0.023	249.0 (57.6)	243.0 (52.5)	0.360
Median [Min, Max]	247.0 [128.0, 441.0]	239.0 [126.0, 434.0]		243.0 [128.0, 441.0]	241.0 [126.0, 434.0]

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