Fig. 2From: Advances in metabolic reprogramming of NK cells in the tumor microenvironment on the impact of NK therapyTumor Microenvironment (drawed by Figdraw). The tumor microenvironment (TME) is the surrounding microenvironment in which tumor cells exist, including the surrounding vasculature, extracellular matrix (ECM), fibroblasts, myeloid-derived inflammatory cells, immune cells, and a variety of cytokines and signaling molecules. Cytokine signaling molecules released by immune cells infiltrated in the TME are involved in mediating immune-suppressive and/or immune-responsive events. DC Dendritic cell, NK CELL Natural killer cell, MDSC Myeloid-derived suppressor cell, CAF Cancer-associated fibroblast, TAM Tumor-associated macrophage, IL Interleukin, TNF-α Tumor necrosis factor-α, CXCL Chemokine, VEGF Vascular endothelial growth factor, TGF-β Transforming growth factor-β, Arg-1 Arginine-1, iNOS Inducible nitric oxide synthase, ROS Reactive oxygen speciesBack to article page