Fig. 3

Metabolic profiles of PBC/AIH VS patients between PR and GR groups. A The flow chart of the metabolic design. B PCA analysis. C The annotation of the detected metabolites. D, E The volcano plot and heatmap of differential metabolites. F The enriched pathway analysis of the differential metabolites. G The joint pathway analysis of differential metabolites and genes. H Heatmap of the differential metabolites involved in the joint pathway analysis. I Correlation analysis between the differential metabolites and clinical indictors. J ROC curves of the differential metabolites. K The relative abundance of metabolites with AUC > 0.7. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001