Fig. 5
From: Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer
Hippo pathway dysregulation from bowel precursor lesions to malignancy. Mechanisms of aberrant YAP/TAZ activation associated with inflammatory bowel disease and adenomas/adenomatous polyps. APC: adenomatous polypolis coli; CREBP: cAMP response element-binding protein; IL-6: interleukin 6/; INF-γ: interferon-gamma; LATS1: large tumor suppressor 1; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; PGE2: prostaglandin E2; PKA: protein kinase A; REG-γ: proteasome activator subunit 3; ROCK1: Rho-associated protein kinase 1; SSP: sessile serrated polyps; YAP: Yes-associated protein