Fig. 4
From: Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer
Hippo pathway dysregulation from pancreas precursor lesions to malignancy. YAP/TAZ aberrant activation is an early event in sporadic and hereditary pancreatitis, pancreatic intraepithelial neoplasia, mucinous cystic lesions and intraductal tubulopapillary neoplasm. ADM: acinar-to ductal metaplasia; CP: chronic pancreatitis; GNAS: guanine nucleotide binding protein, alpha stimulating;IPMN: intraductal papillary mucinous neoplasm; ITPN: intraductal tubular papillary neoplasm;JAK: janus kinase; KRAS: Kirsten rat sarcoma virus; PAF1: polymerase-associated factor 1; PanIN: pancreatic intraepithelial neoplasia; PDAC: Pancreatic ductal adenocarcinoma; PI3K: phosphoinositide 3-kinase; SOX9: sex-determining region Y-box 9; STAT: signal transducer and activator of transcription; TAZ: Transcriptional co-activator with PDZ-binding domain; YAP: Yes-associated protein