Fig. 3
From: Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer
Hippo pathway dysregulation from esophageal precursor lesions to malignancy. Mechanisms contributing to dysfunctional Hippo signaling from normal to neoplastic esophagus across gastroesophageal reflux disease-Barrett esophagus/dysplasia. APE1: apurinic/apyrimidinic endonuclease 1; CSC: cancer stem cell; LOH: loss of heterozygosity; S1PR2: sphingosine 1-phosphate receptor 2; β-TRCP: β-transducin repeat-containing protein; YAP: Yes-associated protein