Fig. 2
From: Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer
Hippo pathway dysregulation from liver precursor lesions to malignancy. Mechanisms contributing to YAP/TAZ aberrant activation in hepatic precancerous lesions (HBV infection, NAFLD/NASH/ASH and liver fibrosis). ANKRD11: cardiac ankyrin repeat protein; ASH: alcoholic steatohepatitis; BMI1: B lymphoma Mo-MLV insertion region 1 homolog; CREBP: cAMP response element-binding protein; CXCL1: CXC motif chemokine ligand 1; CYR61: cysteine-rich angiogenic inducer 61; FKBP5: FK506-binding protein 51;HBsAg: HBV surface antigen; HBV: hepatitis B virus; HBx: hepatitis B virus X protein; HCC: hepatocellular carcinoma; IHH: Indian hedgehog; JCAD: junctional cadherin 5 associated; LATS1: large tumor suppressor 1; MST1/2: serine/threonine kinases sterile 20-like kinase 1 and 2; NAFLD: nonalcoholic fatty liver disease; NASH: nonalcoholic steatohepatitis; NOTCH: neurogenic locus notch homolog protein; TAZ: Transcriptional co-activator with PDZ-binding domainTEAD: TEA domain-containing sequence-specific transcription factors; TGF-β: transforming growth factor beta; YAP: Yes-associated protein