Fig. 1
From: Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer
Hippo signaling pathway and its network. When upstream signals activate the Hippo pathway (Hippo ON), the phosphorylation cascade is enabled that ultimately induces YAP/TAZ proteasomal degradation (leftside). In Hippo OFF conformation, promoted by mechanical signaling and hormones, YAP/TAZ can translocate to the nucleus. Here, by interacting with TEAD transcription factors and cofactors, YAP/TAZ activate the transcription of target genes. ABCP: apico-basal cell polarity protein; AMOT: angiomotin; AMPK: AMP-activated protein kinase; AREG: amphiregulin; CTGF: connective tissue growth factor; CRB: crumbs; CYR61: Cysteine-rich angiogenic inducer 61; KIBRA: kidney and brain expressed protein; NF2: neurofibromin 2; RUNX2: Runt-related transcription factor 2; SCD1: Stearoyl-CoA-desaturase-1; SMAD: small mother against decapentaplegic; TAO: thousand-and-one amino acid