Fig. 4

Validation of core protein expression in the validation cohort. A–H This series compares the expression levels of eight key proteins between Omicron-infected and healthy individuals, illustrating significant differences. I–P Diagnostic Receiver Operating Characteristic (ROC) curves for the same eight core proteins demonstrate their potential as biomarkers for distinguishing between Omicron and healthy samples. The Area Under the Curve (AUC) for all eight hub proteins exceeds 0.7, indicating a promising diagnostic capability. *P < 0.05. **P < 0.01.***P < 0.001. ROC receiver operating characteristic, AUC Area under Curve