Fig. 3

Secondary screening of functional pathway core protein sites. A STRING of 27 differentially expressed proteins (DEPs); B 8 MCODE hub genes:: THBS1, ACTN1, ACTC1, POTEF, ACTB, TPM4, VCL, and ICAM1; C 10 cytohubba-MCC hub genes: THBS1, ACTN1, ACTC1, POTEF, ACTB, TPM4, VCL, ICAM1,PARK7, and YWHAB; D VENN of MCODE hub genes and cytohubba-MCC hub genes: THBS1, ACTN1, ACTC1, POTEF, ACTB, TPM4, VCL, and ICAM1; E Heatmap of 8 hub proteins. F, H Gene Ontology (GO) analysis reveals enrichment in hemostasis, blood microparticle, and integrin binding pathways, while Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways focus on focal adhesion, leukocyte transendothelial migration, and shigellosis