Fig. 2

Analysis procedures for subject inclusion and overall analysis of bioinformation. A The volcano plots of differentially expressed proteins (DEPs); B Principal Component Analysis (PCA) of 2 Groups; C Heatmap of DEPs; D, E Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses reveal the functional categories and pathways enriched among the 27 DEPs. The GO analysis primarily focuses on hemostasis, platelet alpha granule, and integrin binding pathways. The KEGG analysis emphasizes pathways associated with shigellosis, focal adhesion, and leukocyte transendothelial migration. F–H Chord diagrams illustrate the intricate relationships between GO/KEGG terms. BP Biological process, CC Cellular component, MF Molecular function, PCA principal component analysis